Publications
Jenkins MR, Peven JC, Kubic L, Handen BL, Krinsky-McHale SJ, Hom CL, Lee A, Tudorascu DL, McLachlan M, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Rosas HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL; Alzheimer Biomarker Consortium – Down syndrome. Behavioral and psychological symptoms of dementia and Alzheimer’s disease progression in Down syndrome. J Neurodev Disord. 2025 Apr 11;17(1):19. doi: 10.1186/s11689-025-09604-w. PMID: 40217501; PMCID: PMC11987311.
Hillerstrom H, Fisher R, Janicki MP, Chicoine B, Christian BT, Esbensen A, Esralew L, Fortea J, Hartley S, Hassenstab J, Keller SM, Krinsky-McHale S, Lai F, Levin J, McCarron M, McDade E, Rebillat AS, Rosas HD, Silverman W, Strydom A, Zaman SH, Zetterberg H. Adapting prescribing criteria for amyloid-targeted antibodies for adults with Down syndrome. Alzheimers Dement. 2024 May;20(5):3649-3656. doi: 10.1002/alz.13778. Epub 2024 Mar 13. PMID: 38480678; PMCID: PMC11095423.
Janelidze S, Collij LE, Mattsson-Carlgren N, Antill A, Laymon CM, Lott I, Rosas HD, Minhas DS, Luo W, Zaman S; Alzheimer’s Biomarker Consortium–Down Syndrome investigators; Mapstone M, Head E, Lai F, Hartley SL, Ances BM, Krinsky-McHale SJ, Lee JH, Ossenkoppele R, Christian BT, Handen BL, Hansson O. Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study. Lancet Neurol. 2025 Jul;24(7):591-600. doi: 10.1016/S1474-4422(25)00158-9. PMID: 40541209; PMCID: PMC12174012.
DiFilippo AH, Jonaitis EM, Ennis GE, McVea AK, McLachlan M, Bettcher B, Schulz N, Pasquesi ME, Davenport-Sis NJ, Thor Y, Grover E, Chin N, Barnhart TE, Asthana S, Betthauser TJ, Engle JW, Johnson SC, Bendlin BB, Christian BT. Examining the association between synaptic density and neurofibrillary tau among cognitively impaired and unimpaired older adults with and without Alzheimer’s disease pathology. Alzheimers Dement. 2025 Jun;21(6):e70321. doi: 10.1002/alz.70321. PMID: 40465636; PMCID: PMC12136093.
McVea A, DiFilippo A, McLachlan M, Betcher B, Zammit M, Betthauser TJ, Converse A, Murali D, Stone C, Hartley S, Johnson S, Tudorascu DL, Laymon CM, Cohen AD, Minhas D, Luo W, Mathis C, Lao PJ, Ances B, Zaman S, Mapstone M, Head E, Handen BL, Christian BT; ABC‐DS investigators. PET-measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations. Alzheimers Dement. 2025 Jun;21(6):e70357. doi: 10.1002/alz.70357. PMID: 40556306; PMCID: PMC12187968.
McLachlan M, Bettcher B, McVea A, DiFilippo A, Zammit M, LeMerise L, Rouanet J, Price J, Tudorascu D, Laymon C, Keator D, Lao P, Brickman AM, Fryer T, Hartley S, Ances BM, Rosas HD, Johnson S, Betthauser T, Stone CK, Zaman S, Handen B, Head E, Mapstone M, Christian BT, ABC-DS Investigators. The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: Comparison of two radiotracers. Alzheimers Dement. 2025 Apr;21(4):e70141. doi: 10.1002/alz.70141. PMID: 40189783; PMCID: PMC11972983.
Handen BL, Mapstone M, Hartley S, Andrews H, Christian BT, Lee JH, Tudorascu D, Hom C, Ances BM, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Petersen M, O’Bryant S, Harp JP, Schmitt F, Ptomey L, Burns J, Lott IT, Lai F, Silverman W, Laymon C, Head E. The Alzheimer’s Biomarker Consortium-Down Syndrome (ABC-DS): A 10-year report. Alzheimers Dement. 2025 May;21(5):e70294. doi: 10.1002/alz.70294. PubMed PMID: 40371686; PubMed Central PMCID: PMC12079517.
Converse AK, Krasko MN, Rudisch DM, Slesarev MS, Szot JC, Gallagher CL, Ciucci MR. Positron Emission Tomography (PET) Neuroimaging of the Pink1-/- Rat Parkinson Disease Model with the Norepinephrine Transporter (NET) Ligand [18F]NS12137. J Neurosci. 2025 Jul 16;45(29):e0259252025. doi: 10.1523/JNEUROSCI.0259-25.2025. PMID: 40467302; PMCID: PMC12268978.
Edmunds KJ, Nelson AR, Brach TL, Glittenberg M, Christian BT, Betthauser TJ, Johnson SC, Asthana S, Okonkwo OC. Depression modifies age-associated [11C]PiB-PET amyloid burden in a cohort enriched with risk for Alzheimer’s disease. J Alzheimers Dis. 2025 Aug;106(4):1252-1260. doi: 10.1177/13872877251353098. Epub 2025 Jul 10. PMID: 40635663.
Fleming VL, Helsel BC, Ptomey LT, Handen BL, Krinsky-McHale SJ, Hom CL, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Brickman AM, Pulsifer M, Clare ICH, Rosa HD, Lai F, Harp J, Schmitt F, Price J, Zaman SH, Head E, Mapstone M, Christian BT, Okonkwo O, Hartley SL; Alzheimer’s Biomarkers Consortium–Down Syndrome. Longitudinal study of body mass index in relation to Alzheimer’s disease pathology and symptomatology in Down syndrome. Alzheimers Dement. 2025 Jun;21(6):e70387. doi: 10.1002/alz.70387. PMID: 40545561; PMCID: PMC12183108.
Higgins ET, Busse WW, Esnault S, Christian BT, Klaus DR, Bach JC, Frye CJ, Rosenkranz MA. Fueling the fire in the lung-brain axis: The salience network connects allergen-provoked TH17 responses to psychological stress in asthma. Brain Behav Immun. 2025 Apr 8;128:276-288. doi: 10.1016/j.bbi.2025.04.004. Epub ahead of print. PMID: 40209864.
LeMerise LG, Guerrero-Gonzalez J, McVea A, Zammit M, Kecskemeti S, Hartley S, Head E, Mapstone M, Handen B, Alexander A, Christian B; ABC‐DS Investigators. Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome. Alzheimers Dement. 2025 Aug;21(8):e70572. doi: 10.1002/alz.70572. PMID: 40779433; PMCID: PMC12333877.
Schworer EK, Handen BL, Krinsky-McHale S, Hom CL, Clare ICH, Harp JP, Pulsifer MB, Mapstone M, Head E, Christian BT, Hartley SL. Modified Cued Recall Test: Longitudinal Analysis of Test Versions and Item Recall in Adults With Down Syndrome. J Intellect Disabil Res. 2025 Apr 20;. doi: 10.1111/jir.13237. [Epub ahead of print] PubMed PMID: 40254895; NIHMSID:NIHMS2085132.
Zammit MD, Price JC, Christian BT, Rafii MS; Alzheimer’s Biomarker Consortium – Down Syndrome. A head-to-head comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials. medRxiv [Preprint]. 2025 Mar 19:2025.03.18.25324200. doi: 10.1101/2025.03.18.25324200. PMID: 40166579; PMCID: PMC11957079. Brain Communications (In Press).
Clina JG, Helsel BC, Hartley SL, Fleming-Batayneh VL, Handen B, Christian B, Head E, Mapstone M, Hom CL, Burns J, Ances B, Ptomey LT; Alzheimer Biomarker Consortium–Down Syndrome (ABC-DS) Investigators. The joint association of obesity and physical activity on cognitive function in Down syndrome. J Alzheimers Dis. 2025 Oct 16:13872877251386474. doi: 10.1177/13872877251386474. Epub ahead of print. PMID: 41100837.
Cody KA, Langhough RE, Zammit MD, Clark L, Chin N, Christian BT, Betthauser TJ, Johnson SC. Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer’s disease. Brain. 2024 Jun 3;147(6):2144-2157. doi: 10.1093/brain/awae116. PMID: 38667631; PMCID: PMC11146417.
McVea A, Choi Y, DiFilippo A, McLachlan M, Bettcher B, Zammit M, Stone CK, Tudorascu D, Mukherjee J, Christian BT. Age and Sex Related Differences in Human α4β2* Nicotinic Acetylcholine Receptor Binding Evaluated with [18F]nifene PET. Imaging Neuroscience 2024; doi: https://doi.org/10.1162/imag_a_00397
Lao P, Edwards N, Flores-Aguilar L, Alshikho M, Rizvi B, Tudorascu D, Rosas HD, Yassa M, Christian BT, Mapstone M, Handen B, Zimmerman ME, Gutierrez J, Wilcock D, Head E, Brickman AM. Cerebrovascular disease emerges with age and Alzheimer’s disease in adults with Down syndrome. Sci Rep. 2024 May 29;14(1):12334. doi: 10.1038/s41598-024-61962-y. PMID: 38811657; PMCID: PMC11137035.
Converse AK, Krasko MN, Rudisch DM, Lunaris CL, Nisbet AF, Slesarev MS, Szot JC, Hoerst AG, Leverson GE, Gallagher CL, Ciucci MR. Positron emission tomography neuroimaging of [18F]fluorodeoxyglucose uptake and related behavior in the Pink1-/- rat model of Parkinson disease. Front Neurosci. 2024 Oct 15;18:1451118. doi: 10.3389/fnins.2024.1451118. PMID: 39474461; PMCID: PMC11520326.
Schworer EK*, Zammit MD*, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Christian BT, Hartley SL & ABC-DS Investigators. Amyloid and tau PET timeline to symptomatic Alzheimer’s disease in Down syndrome: Longitudinal cohort study. Lancet Neurology 2024; 23(12); 1214-1224. doi.org/10.1016/S1474-4422(24)00426-5.